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1

Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists

Emily M. Stocking, Leah Aluisio, John R. Atack, Pascal Bonaventure, Nicholas I. Carruthers, Christine Dugovic, Anita Everson, Ian Fraser, Xiaohui Jiang, Perry Leung, Brian Lord, Kiev S. Ly, Kirsten L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 574 KB

english, 2010

2

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development

Michael A. Letavic, Leah Aluisio, John R. Atack, Pascal Bonaventure, Nicholas I. Carruthers, Christine Dugovic, Anita Everson, Mark A. Feinstein, Ian C. Fraser, Kenway Hoey, Xiaohui Jiang, John M. Kei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

3

Functional role of 5-HT2receptors in the regulation of sleep and wakefulness in the rat

Christine Dugovic, Albert Wauquier, Josee E. Leysen, Roger Marrannes, Paul A. J. Janssen

Journal:

Psychopharmacology

Year:

1989

Language:

english

File:

PDF, 821 KB

english, 1989

4

Effects of ritanserin and chlordiazepoxide on sleep-wakefulness alterations in rats following chronic cocaine treatment

Christine Dugovic, Theo F. Meert, David Ashton, Gilbert H. C. Clincke

Journal:

Psychopharmacology

Year:

1992

Language:

english

File:

PDF, 888 KB

english, 1992

5

Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines

Curt A. Dvorak, Richard Apodaca, Wei Xiao, Jill A. Jablonowski, Pascal Bonaventure, Christine Dugovic, Jonathan Shelton, Brian Lord, Kirsten Miller, Lisa K. Dvorak, Timothy W. Lovenberg, Nicholas I. C

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 973 KB

english, 2009

6

The light-dark cycle modulates the effects of ritanserin on sleep-wakefulness patterns in the rat

Christine Dugovic, Josee E. Leysen, Paul F.M. Janssen, Albert Wauquier

Journal:

Pharmacology Biochemistry and Behavior

Year:

1989

Language:

english

File:

PDF, 473 KB

english, 1989

7

Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor

Ann J. Barbier, Leah Aluisio, Brian Lord, Ying Qu, Sandy J. Wilson, Jamin D. Boggs, Pascal Bonaventure, Kirsten Miller, Ian Fraser, Lisa Dvorak, Cindy Pudiak, Christine Dugovic, Jonathan Shelton, Curt

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 568 KB

english, 2007

8

Functional activity of 5-HT2 receptors in the modulation of the sleep/wakefulness states

CHRISTINE DUGOVIC

Journal:

Journal of Sleep Research

Year:

1992

Language:

english

File:

PDF, 550 KB

english, 1992

9

β1 and β2 adrenergic receptors: Their role in the regulation of paradoxical sleep in the rat

Laurence Lanfumey, Christine Dugovic, Joëlle Adrien

Journal:

Electroencephalography and Clinical Neurophysiology

Year:

1985

Language:

english

File:

PDF, 693 KB

english, 1985

10

Presence of a paradoxical sleep (PS) factor in the cerebrospinal fluid of PS-deprived rats

Joëlle Adrien, Christine Dugovic

Journal:

European Journal of Pharmacology

Year:

1984

Language:

english

File:

PDF, 254 KB

english, 1984

11

5-HT2 receptors could be primarily involved in the regulation of slow-wabe sleep in the rat

Christine Dugovic, Albert Wauquier

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 141 KB

english, 1987

12

5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor

Jonathan Shelton, Pascal Bonaventure, Xiaorong Li, Sujin Yun, Timothy Lovenberg, Christine Dugovic

Journal:

Neuropharmacology

Year:

2009

Language:

english

File:

PDF, 307 KB

english, 2009

13

The selective neurokinin 1 receptor antagonist R116301 modulates photic responses of the hamster circadian system

Etienne Challet, Christine Dugovic, Fred W. Turek, Olivier Van Reeth

Journal:

Neuropharmacology

Year:

2001

Language:

english

File:

PDF, 214 KB

english, 2001

14

Sleep-wakefulness patterns in the helpless rat

Joëlle Adrien, Christine Dugovic, Patrick Martin

Journal:

Physiology & Behavior

Year:

1991

Language:

english

File:

PDF, 572 KB

english, 1991

15

Melatonin modulates the sensitivity of 5-hydroxytryptamine-2 receptor-mediated sleep—wakefulness regulation in the rat

Dugovic, Christine, Leysen, Josee E., Wauquier, Albert

Journal:

Neuroscience Letters

Year:

1989

Language:

english

File:

PDF, 320 KB

english, 1989

16

Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

Letavic, Michael A., Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J., Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Fraser, Ian C., Kramer, Michel

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 330 KB

english, 2015

17

Novel Octahydropyrrolo[3,4- c ]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate

Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, P

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 830 KB

english, 2015

18

Effects of Lithium on Dopamine Behavioural Supersensitivity Induced by Rapid Eye Movement Sleep Deprivation

Arriaga, Filipe, Dugovic, Christine, Wauquier, Albert

Journal:

Neuropsychobiology

Year:

1988

File:

PDF, 1.11 MB

1988

19

Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression

Dugovic, Christine, Solberg, Leah C., Redei, Eva, Reeth, Olivier Van, Turek, Fred W.

Journal:

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

20

Similar genetic mechanisms may underlie sleep???wake states in neonatal and adult rats

Dugovic, Christine, Turek, Fred W.

Journal:

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

21

Diurnal Sex Differences in the Sleep-Wake Cycle of Mice are Dependent on Gonadal Function

Paul, Ketema N., Dugovic, Christine, Turek, Fred W., Laposky, Aaron D.

Journal:

Year:

2006

Language:

english

File:

PDF, 695 KB

english, 2006

22

Deletion of the Mammalian Circadian Clock Gene BMAL1/Mop3 Alters Baseline Sleep Architecture and the Response to Sleep Deprivation

Laposky, Aaron, Easton, Amy, Dugovic, Christine, Walisser, Jacqueline, Bradfield, Christopher, Turek, Fred

Journal:

Year:

2005

Language:

english

File:

PDF, 3.31 MB

english, 2005

23

Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope

Berdyyeva, Tamara, Otte, Stephani, Aluisio, Leah, Ziv, Yaniv, Burns, Laurie D., Dugovic, Christine, Yun, Sujin, Ghosh, Kunal K., Schnitzer, Mark J., Lovenberg, Timothy, Bonaventure, Pascal, Amédée, Th

Journal:

Year:

2014

Language:

english

File:

PDF, 1.28 MB

english, 2014

24

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Shelton, Jonathan, Yun, Sujin, Losee Olson, Susan, Turek, Fred, Bonaventure, Pascal, Dvorak, Curt, Lovenberg, Timothy, Dugovic, Christine

Journal:

Frontiers in Behavioral Neuroscience

Year:

2015

Language:

english

File:

PDF, 831 KB

english, 2015

25

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Yun, Sujin, Wennerholm, Michelle, Shelton, Jonathan E., Bonaventure, Pascal, Letavic, Michael A., Shireman, Brock T., Lovenberg, Timothy W., Dugovic, Christine

Journal:

Frontiers in Behavioral Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

26

Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

Aluisio, Leah, Fraser, Ian, Berdyyeva, Tamara, Tryputsen, Volha, Shireman, Brock T., Shoblock, James, Lovenberg, Timothy, Dugovic, Christine, Bonaventure, Pascal

Journal:

Frontiers in Neuroscience

Year:

2014

Language:

english

File:

PDF, 1.68 MB

english, 2014

27

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

Dugovic, Christine, Shelton, Jonathan E., Yun, Sujin, Bonaventure, Pascal, Shireman, Brock T., Lovenberg, Timothy W.

Journal:

Frontiers in Neuroscience

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

28

Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice

Berdyyeva, Tamara K., Frady, E. Paxon, Nassi, Jonathan J., Aluisio, Leah, Cherkas, Yauheniya, Otte, Stephani, Wyatt, Ryan M., Dugovic, Christine, Ghosh, Kunal K., Schnitzer, Mark J., Lovenberg, Timoth

Journal:

Frontiers in Neuroscience

Year:

2016

Language:

english

File:

PDF, 2.12 MB

english, 2016

29

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D.

Journal:

Frontiers in Pharmacology

Year:

2017

Language:

english

File:

PDF, 2.18 MB

english, 2017

30

S170. In Vivo Characterization of an Orally Available, Brain Penetrant Small Molecule GPR139 Agonist

Shoblock, James, Welty, Natalie, Fraser, Ian, Wyatt, Ryan, Dugovic, Christine, Chen, Guang, Lovenberg, Tim, Liu, Changlu, Bonaventure, Pascal

Journal:

Biological Psychiatry

Year:

2018

Language:

english

File:

PDF, 44 KB

english, 2018

31

Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor

Wyatt, Ryan M, Fraser, Ian, Welty, Natalie, Lord, Brian, Wennerholm, Michelle, Sutton, Steven W, Ameriks, Michael K, Dugovic, Christine, Yun, Sujin, White, Allison, Nguyen, Leslie, Koudriakova, Tatian

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2019

File:

PDF, 1.64 MB

2019

32

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

PrÃ©ville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J., Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 318 KB

2020

33

Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models

Wang, Lien, Dugovic, Christine, Yun, Sujin, White, Allison, Lord, Brian, Dvorak, Curt, Liu, Changlu, Lovenberg, Timothy, Bonaventure, Pascal

Journal:

European Journal of Pharmacology

Year:

2020

File:

PDF, 2.13 MB

2020

34

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

Salvadore, Giacomo, Bonaventure, Pascal, Shekhar, Anantha, Johnson, Philip L., Lord, Brian, Shireman, Brock T., Lebold, Terry P., Nepomuceno, Diane, Dugovic, Christine, Brooks, Sander, Zuiker, Rob, Bl

Journal:

Translational Psychiatry

Year:

2020

File:

PDF, 549 KB

2020